Serum ferritin and obstructive coronary artery disease: angiographic correlation.

OBJECTIVE: To verify the possible association between the levels of serum ferritin and the degree of obstructive coronary artery disease. METHODS: 115 patients with coronary arteriography and concomitant evaluation of serum ferritin were studied. The adopted cut-off values were 80 ng/ml for women and 120 ng/ml for men. RESULTS: The mean ferritin levels for males and females were 133.9 +/- 133.8 ng/ml and 214.6 +/- 217.2 ng/ml, respectively (p=0.047). It was observed that 44.1% of the women had normal serum ferritin levels in comparison to 30.9% of the men (p=0.254). In the patients without obstructive coronary artery disease or with less severe obstructions (group A) the serum ferritin level was 222.3 +/- 325 ng/ml. On the other hand, for those with moderate (group B) and severe obstructions (group C) the levels were 145.6+-83.7 ng/ml and 188.9 +/- 150.6 ng/ml, respectively. There was no correlation between the degree of coronary artery disease and the mean level of serum ferritin. Regarding the cut-off value, the number of women with serum ferritin level > 80 ng/ml in groups B+C or only C was significantly higher than the number of women in group A (ODDS RATIO 9.71 with 95%CI from 1.63 to 57.72). For males there was no significant difference between the number of cases above or below the cut-off values (ODDS RATIO 0.92 with 95%CI from 0.28 to 2.95). CONCLUSION: It was verified that women with serum ferritin levels > 80 ng/mL presented more severe obstructive coronary artery disease than women with lower levels. In men, the serum ferritin level was not a predictor element of the degree of obstruction.

Ferritina sérica e coronariopatia obstrutiva: correlação angiográfica / Serum ferritin and obstructive coronary artery disease: angiographic correlation

OBJETIVO: Verificar a possível associação entre os valores séricos de ferritina e o grau de coronariopatia obstrutiva. MÉTODOS: Foram estudados 115 pacientes com cinecoronariografia e concomitante dosagem sérica de ferritina. Os valores de corte adotados foram 80 ng/ml para mulheres, e 120 ng/ml para homens. RESULTADOS: As ferritinemias médias nos sexos masculino e feminino foram, respectivamente, 133,9±133,8 ng/ml 214,6±217,2 ng/ml (p=0,047). Observou-se que 44,1 por cento das mulheres se apresentavam com ferritinemia normal, contra 30,9 por cento dos homens (p=0,254). Nos pacientes sem coronariopatia obstrutivas ou com obstruções discretas (grupo A), a ferritinemia foi de 222,3±325 ng/ml. Já para as obstruções moderadas (grupo B) e graves (grupo C), os níveis foram, respectivamente, 145,6±83,7 ng/ml e 188,9±150,6 ng/ml. Não houve correlação entre o grau de coronariopatia e o nível de ferritina sérica quanto à ferritinemia média. Em relação ao valor de corte, a quantidade de mulheres com ferritina acima de 80 ng/ml que se encontravam nos grupos B+C ou somente C foi significativamente maior que a quantidade de mulheres no grupo A (Odds Ratio 9,71 com IC95 por cento de 1,63 a 57,72). Já no sexo masculino, constataram-se graus similares de coronariopatia tanto acima como abaixo de valor de corte (Odds Ratio 0,92 com IC95 por cento de 0,28 a 2,95). CONCLUSÃO: Constatou-se que mulheres com níveis de ferritinemia acima de 80 ng/ml apresentaram significativamente mais coronariopatia obstrutiva de grau importante que mulheres com taxas abaixo daquele valor. Em homens, a ferritinemia não foi elemento preditor do grau de obstrução.

OBJECTIVE: To verify the possible association between the levels of serum ferritin and the degree of obstructive coronary artery disease. METHODS: 115 patients with coronary arteriography and concomitant evaluation of serum ferritin were studied. The adopted cut-off values were 80 ng/ml for women and 120 ng/ml for men. RESULTS: The mean ferritin levels for males and females were 133.9±133.8 ng/ml and 214.6±217.2 ng/ml, respectively (p=0.047). It was observed that 44.1 percent of the women had normal serum ferritin levels in comparison to 30.9 percent of the men (p=0.254). In the patients without obstructive coronary artery disease or with less severe obstructions (group A) the serum ferritin level was 222.3±325 ng/ml. On the other hand, for those with moderate (group B) and severe obstructions (group C) the levels were 145.6+-83.7 ng/ml and 188.9±150.6 ng/ml, respectively. There was no correlation between the degree of coronary artery disease and the mean level of serum ferritin. Regarding the cut-off value, the number of women with serum ferritin level > 80 ng/ml in groups B+C or only C was significantly higher than the number of women in group A (ODDS RATIO 9.71 with 95 percentCI from 1.63 to 57.72). For males there was no significant difference between the number of cases above or below the cut-off values (ODDS RATIO 0.92 with 95 percentCI from 0.28 to 2.95). CONCLUSION: It was verified that women with serum ferritin levels > 80 ng/mL presented more severe obstructive coronary artery disease than women with lower levels. In men, the serum ferritin level was not a predictor element of the degree of obstruction.